Canadian investigators went beyond the EPCAT II trial (1) and presented the EPCAT III study at the Congress of the International Society on Thrombosis and Haemostasis (ISTH) 2026 in Paris. The double-blind randomized trial, simultaneously published in the New England Journal of Medicine, compared antithrombotic prophylaxis with aspirin (ASA) alone versus rivaroxaban followed by ASA after hip or knee arthroplasty (2).

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